Peptide bioregulators aren’t very well known by the mainstream. They are something I have been studying for close to 10 years or so now. They have been around for a long time, first developed in the 1970’s in the Military Medical Academy in Russia, and have a lot of research behind them. Most of the research comes from Professor Vladamir Khavison. You will see peptide bioregulators sold as Khavison peptides or Khavison bioregulators at times. The peptides were initially developed on behalf of and used by the Soviet Union Military, Cosmonaut space program, and their Olympic athletes. There are 2 reasons why peptide bioregulators aren’t very well known in the west; the Russians have patents on them and have done most, if not all of the research, and the way peptide bioregulators are synthesised isn’t easy for Big Pharma to commercialize.
A peptide is a sequence of 50 amino acids or less. The
bioregulators are shorter peptides, normally a chain of 2, 3, or 4 amino acids
in length. The shorter the peptide sequence, the more specific its effects. For
example, the heart peptide bioregulator will only interact with genes
associated with the heart. Peptide bioregulators are not the same as normal/commonly
known peptides like BPC-157 or TB-500. They come in capsules or tablets whereas
other peptides have to be injected as they get destroyed by the stomach before
they are able to be absorbed. The short sequence of amino acids allows them to
be absorbed and utilised by the body even when taken orally. There are also
sublingual options available. Two peptide bioregulators that are probably most
well-known are Epitalon® and Thymalin®. They are well known for their ability
to lengthen telomeres and extend lifespan, and more importantly, healthspan.
Bioregulators are natural substances produced in our body
that try to regulate or repair systems and get us back into a healthy state.
They can also be found in food; the extracts are just stronger and more precise
than trying to obtain them from food sources. Peptide bioregulators are sourced
from food molecules derived from young calves. Peptides are signalling
molecules. They regulate the immune, nervous, and endocrine system. Peptides
support many key processes in the body due to their antioxidant, antimicrobial,
antibacterial, anti-inflammatory, anticarcinogenic, antitumor, and
immunoregulatory characteristics. Peptide bioregulators have a molecular structure
that the body is familiar with and “knows” what to do with them when ingested.
They repair tissue by accelerating protein synthesis, regulating gene
expression, and they directly interact with cellular DNA.
Peptide bioregulators are very specific in their actions.
There is a peptide bioregulator for pretty much every gland, organ, and system
of the body. Traditional peptides tend to have more systemic benefits. With
peptide bioregulators, as long as you have a gland that is still functioning to
some capacity, they are able to help regenerate / improve the functioning of
that gland / body part. Peptide bioregulators take a little bit longer than
traditional peptides to have a noticeable effect. They are more for long term
regeneration / optimization of certain body systems.
The beauty of peptide bioregulators is that as the name
suggests, they “regulate” / balance / modulate body systems, and don’t over
stimulate or shut off the gland. For example, if someone is hypothyroid and
takes the thyroid peptide bioregulator, it will help the thyroid produce more
thyroid hormones but if the patient is hyperthyroid, it won’t do so. Peptide
bioregulators can’t produce supraphysiological levels of hormones like hormone
replacement therapy could if not monitored correctly.
Another benefit to using peptide bioregulators is there is
no down regulation of receptor activity, no shutting down the production of the
gland / system through negative feedback mechanisms. For example, if you take
testosterone, you can shut down your natural production of testosterone and
need to depend on hormone replacement to keep optimal levels. This isn’t the
case with peptide bioregulators and why it would be a good idea to try and
support the HPA axis, testes etc. with peptide bioregulators to maintain /
optimize their natural function before starting testosterone replacement
therapy. Again, all lifestyle factors should be addressed, not just taking a
peptide bioregulator and thinking it is a magic bullet.
There are two main types of peptide bioregulators;
· Natural
peptide extracts known as cytomaxes and
· Synthetic
regulatory peptides also known as cytogens
Cytomaxes are bioregulators from animal tissues or organs,
and are labelled A-1, A-2, A-3 etc.
Cytogens are bioregulators that are synthetically made in a
lab from amino acids, and are labelled AC-2, AC-3, AC-4 etc.
There are also cytamins which are bioregulators from animal
origin that also have amino acids and vitamins added to them. We will talk
about cytomaxes and cytogens as that is where the research has been done and
what most people have used over the years.
The cytogens (synthetic) bioregulators are faster acting,
and the cytomaxes (natural) have long term effects. Typically, if someone has a
disease or issue that needs urgent care, they take the cytogens (synthetic) for
a couple of weeks to a month, and then begin to take the cytomaxes (naturals)
for long term healing / regeneration.
Peptide bioregulators don’t need to be put into the body
every single day. They have lasting effects and can be used monthly, quarterly,
or even half yearly, depending on the health and goal of the individual.
If you are trying to correct an organ, gland, body system,
or have some sort of disease state that you are trying to fix, you can do an
intensive course which is 2 capsules per day for 30 days, 60 capsules.
After this initial 30 days, you can drop down to 2 capsules
a day for 10 days, 20 caps per month, and do this monthly.
Then, once you feel you are on top of things, you can
reduce your dose down to a maintenance of 2 capsules per day, for 10 days,
every 3 months. Eventually, you may even go to every 6 months.
If you are younger, you would take them less often, as you
age, you would do every 3 months.
A generally healthy person who wants to protect / enhance a
particular system can take 2 capsules a day for 10-days and then repeat the
course 6 months later.
Stacking the peptide bioregulators works better than just
taking one. They are never really used alone. The best results always come when
peptide bioregulators are used in combination as health is not derived from
just one organ or gland. The blood vessel bioregulator Vesugen® or Ventfort®
tend to be a great addition to any stack. In Russia, when Professor Khavison
used them with athletes for rehabilitation and restoration, they used a
combination of 6 peptide bioregulators “the best effects were from a
combination of 6 peptide bioregulators, those being blood vessels, brain,
thymus, cartilage, heart, and liver. This combination was recommended and used
after a lot of scientific work.” They have also used them with cosmonauts and
elite military forces.
In a large study on factory workers Professor Khavison saw
2.8 times less illness and morbidity compared to the control group “we had a
long-term study of people working in factories. It was a large company called
GAZPROM, responsible for the country’s gas supply. The participants worked in
Siberia, which as you know is a harsh climate. We had 11,000 people in our
study… 3000 of the 11,000 were the control group, the remainder were divided
into different groups using the blood vessel, thymus and pineal peptides, or
combinations of them. We found that in the peptide bioregulator groups there
was less ill health and morbidity compared to the control group, in fact it was
2.8 times less. It is a massive difference, to be nearly 3 times less likely to
be ill.” These workers were 35 – 60 years old.
In another study on factory workers in the Soviet Union, Professor
Khavison found that workers had 2.5 times less illness and morbidity than the
control group. So, results have been reproducible.
In all these studies, they only used the natural peptide
bioregulators as they wanted to test safety and efficacy.
They also used peptide bioregulators with people who were
trying to clean up the contamination at Chernobyl. These people were exposed to
very high radiation levels, so they used higher doses. The workers mortality
rate actually got lower than the average mortality rate across the country at
the time.
Peptide bioregulators have also been successful at
preventing retina pigmentosa
from progressing to complete vision loss. It is a generic disease and there is
no cure for it. Patients who suffer from this disease are told there isn’t
anything they can do for it other than manage the symptoms and hopefully slow
the rate of vision loss. The peptide bioregulators have helped keep vision in
cases of retina pigmentosa.
You could take all 21 natural bioregulators and once and not
experience any cross over effects or things like that. They are very specific
in their actions as mentioned above. If you did want to take all of the peptide
bioregulators, you could take 3 to 6 at a time and rotate them throughout the
year so that you end up taking each of them at least twice per year.
Peptide bioregulators are very safe. They have been used in
Russia for over 30 years with no negative side effects. Long term
administration of doses between 100 to 1000 times the regular therapeutic doses
has not reported any side effects.
Cytomaxes (natural)
|
A-1 |
suprefort® |
Pancreas peptide
bioregulator |
|
A-2 |
thyreogen® |
Thyroid peptide
bioregulator |
|
A-3 |
ventfort® |
Blood vessel peptide
bioregulator |
|
A-4 |
sigumir® |
Cartilage peptide
bioregulator |
|
A-5 |
cerluten® |
Nervous system
peptide bioregulator |
|
A-6 |
vladonix® |
Thymus peptide
bioregulator |
|
A-7 |
svetinorm® |
Liver peptide
bioregulator |
|
A-8 |
endoluten® |
Pineal peptide
bioregulator |
|
A-9 |
pielotax® |
Kidney peptide
bioregulator |
|
A-10 |
stamakort® |
Stomach peptide
bioregulator |
|
A-11 |
visoluten® |
Retina peptide
bioregulator |
|
A-12 |
chitomur® |
Bladder peptide
bioregulator |
|
A-13 |
testoluten® |
Testes peptide
bioregulator |
|
A-14 |
chelohart® |
Heart peptide
bioregulator |
|
A-15 |
zhenoluten® |
Ovary peptide
bioregulator |
|
A-16 |
libidon® |
Prostate peptide
bioregulator |
|
A-17 |
glandokort® |
Adrenal peptide
bioregulator |
|
A-18 |
gotratix® |
Muscle peptide
bioregulator |
|
A-19 |
taxorest® |
Lung peptide
bioregulator |
|
A-20 |
bonomarlot® |
Bone marrow peptide
bioregulator |
|
A-21 |
bonthyrk® |
Parathyroid peptide
bioregulator |
Cytogens (synthetic)
|
AC-2 |
Vesugen® |
Blood vessel peptide
bioregulator |
|
AC-3 |
Ovagen® |
Liver and gastrointestinal
tract peptide bioregulator |
|
AC-4 |
Cartalax® |
Cartilage and bone
tissue peptide bioregulator |
|
AC-5 |
Pinealon® |
Brain cell peptide
bioregulator |
|
AC-6 |
Crystagen® |
Immune system peptide
bioregulator |
|
AC-7 |
Chonluten® |
Lung and bronchial
mucosa peptide bioregulator |
There are many other bioregulators such as cortagen,
cortexin, vesugen, pinealon, bronchogen, thymogen, vilon, normoftal, cardiogen,
epitalon, thymalin, testagen, livagen, and many more.
This is a quick overview of peptide bioregulators. We will
go over individual peptide bioregulators and their benefits in the future.
References / further reading:
https://www.mdpi.com/1420-3049/26/22/7053
https://www.youtube.com/watch?v=koDLR44k7uI
https://www.antiaging-systems.com/articles/peptide-bioregulators-in-sports-and-space/
The Peptide Bioregulator Revolution
https://www.youtube.com/watch?v=NyShaC_a6eU
https://www.youtube.com/watch?v=K06YkttTeTU
Peptides in the epigenic control of ageing
https://www.antiaging-systems.com/articles/the-new-russian-peptide-revolution/
https://aging-matters.com/reversing-biological-aging-with-peptide-bioregulators/
https://www.youtube.com/watch?v=HIUjBJLJM5Q
